USE OF DESIRABILITY FUNCTIONS ASSOCIATED WITH A CHEMOMETRIC METHOD TOOPTIMIZE SEPARATION OF A COMPOUND MIXTURE BY LIQUID-CHROMATOGRAPHY

Authors
GUILLAUME Y PEYRIN E GUINCHARD C
Citation
Y. Guillaume et al., USE OF DESIRABILITY FUNCTIONS ASSOCIATED WITH A CHEMOMETRIC METHOD TOOPTIMIZE SEPARATION OF A COMPOUND MIXTURE BY LIQUID-CHROMATOGRAPHY, Journal of AOAC International, 80(2), 1997, pp. 436-438
Citations number
14
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of AOAC International → ACNP
ISSN journal
10603271
Volume
80
Issue
2
Year of publication
1997
Pages
436 - 438
Database
ISI
SICI code
1060-3271(1997)80:2<436:UODFAW>2.0.ZU;2-Q
Abstract
A chemometric method using a desirability function was used to optimiz e the liquid chromatographic separation of 10 benzodiazepines in a min imum analysis time. Most efficient separation was achieved with aceton itrile-water (60 + 40) at a flow rate of 1 mL/min and a column tempera ture of 47 degrees C.