ANTAGONISM OF THE INHIBITORY-ACTION OF NEUROPEPTIDE-Y (NPY) IN GUINEA-PIG TRACHEA BY THE C-TERMINAL FRAGMENT NPY (2-36)

Citation
Mt. Benchekroun et al., ANTAGONISM OF THE INHIBITORY-ACTION OF NEUROPEPTIDE-Y (NPY) IN GUINEA-PIG TRACHEA BY THE C-TERMINAL FRAGMENT NPY (2-36), British Journal of Pharmacology, 109(4), 1993, pp. 902-904
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
00071188
Volume
109
Issue
4
Year of publication
1993
Pages
902 - 904
Database
ISI
SICI code
0007-1188(1993)109:4<902:AOTION>2.0.ZU;2-W
Abstract
The C-terminal fragment of neuropeptide Y (NPY), NPY(2-36) was used as a means of discriminating between two differently located NPY recepto r sites in guinea-pig trachea. Both NPY and NPY(2-36) reduced the maxi mal relaxation elicited by vasoactive intestinal peptide (VIP). In con trast, the C-terminal fragment did not mimic the inhibitory action of NPY on the noradrenaline-(NA) evoked response. However, pretreatment o f the trachea with 30 nm NPY(2-36), 5 min before generating NA and VIP concentration-response curves in the presence of NPY, abolished the i nhibitory effect of NPY on NA-elicited response but did not affect the modulatory action of NPY on VIP-induced relaxation. These results sug gest that the two differently located NPY receptor sites in guinea-pig trachea are of two distinct subpopulations.