EFFICACY OF SKIN BARRIER CREAMS .2. INEFFECTIVENESS OF A POPULAR SKINPROTECTOR AGAINST VARIOUS IRRITANTS IN THE REPETITIVE IRRITATION TESTIN THE GUINEA-PIG

Authors
FROSCH PJ SCHULZEDIRKS A HOFFMANN M AXTHELM I
Citation
Pj. Frosch et al., EFFICACY OF SKIN BARRIER CREAMS .2. INEFFECTIVENESS OF A POPULAR SKINPROTECTOR AGAINST VARIOUS IRRITANTS IN THE REPETITIVE IRRITATION TESTIN THE GUINEA-PIG, Contact dermatitis, 29(2), 1993, pp. 74-77
Citations number
9
Categorie Soggetti
Allergy,"Dermatology & Venereal Diseases
Journal title
Contact dermatitis → ACNP
ISSN journal
01051873
Volume
29
Issue
2
Year of publication
1993
Pages
74 - 77
Database
ISI
SICI code
0105-1873(1993)29:2<74:EOSBC.>2.0.ZU;2-H
Abstract
A popular ''skin protector'' consisting of an emulsion-like foam of li pophilic and hydrophilic substances (Marly skin(R)) was evaluated in a previously described repetitive irritation guinea pig model. The prod uct failed to inhibit the irritation due to sodium lauryl sulphate and toluene. In striking contrast to the recommended use, the irritant re sponse of sodium hydroxide was aggravated, as demonstrated by signific ant differences for all test parameters (clinical score for erythema a nd scaling, transepidermal water loss, blood flow volume). The results show that protection against chemical irritants may be quite specific and that some formulations may actually be harmful.