CHANGES IN COMPLEMENT AND IMMUNOGLOBULIN-G RECEPTOR EXPRESSION ON NEUTROPHILS ASSOCIATED WITH PORPHYROMONAS-GINGIVALIS-INDUCED INHIBITION OF PHAGOCYTOSIS

We examined the phagocytic capacity and receptor expression on neutrop hils stimulated with Porphyromonas gingivalis soluble products. Stimul ated neutrophils had decreased phagocytic capacities and altered expre ssion of CR1, CR3, FcgammaRII, and FcgammaRIII. For cases in which TLC K (N-alpha-p-tosyl-L-lysine chloromethyl ketone) neutralized the effec ts of the stimuli, the P. gingivalis-derived factors causing the pheno mena seem to be trypsin-like proteases.