PROTECTION AGAINST MURINE DISSEMINATED CANDIDIASIS MEDIATED BY A CANDIDA-ALBICANS-SPECIFIC T-CELL LINE

Authors
SIECK TG MOORS MA BUCKLEY HR BLANK KJ
Citation
Tg. Sieck et al., PROTECTION AGAINST MURINE DISSEMINATED CANDIDIASIS MEDIATED BY A CANDIDA-ALBICANS-SPECIFIC T-CELL LINE, Infection and immunity, 61(8), 1993, pp. 3540-3543
Citations number
29
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
61
Issue
8
Year of publication
1993
Pages
3540 - 3543
Database
ISI
SICI code
0019-9567(1993)61:8<3540:PAMDCM>2.0.ZU;2-1
Abstract
The role of T lymphocytes in disseminated candidiasis in a mouse model of irradiation-induced immunosuppression was investigated. A continuo usly cultured Candida albicans-specific T-cell line mediated protectio n of sublethally irradiated mice from disseminated candidiasis as meas ured by both the fungal load in the kidneys and mortality. These resul ts are the first to demonstrate directly a role for antigen-specific T cells in the protective immune response against murine disseminated c andidiasis.