PRONOUNCED ENHANCEMENT OF .NO-DEPENDENT ANTIMICROBIAL ACTION BY AN .NO-OXIDIZING AGENT, IMIDAZOLINEOXYL N-OXIDE

Authors
YOSHIDA K AKAIKE T DOI T SATO K IJIRI S SUGA M ANDO M MAEDA H
Citation
K. Yoshida et al., PRONOUNCED ENHANCEMENT OF .NO-DEPENDENT ANTIMICROBIAL ACTION BY AN .NO-OXIDIZING AGENT, IMIDAZOLINEOXYL N-OXIDE, Infection and immunity, 61(8), 1993, pp. 3552-3555
Citations number
24
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
61
Issue
8
Year of publication
1993
Pages
3552 - 3555
Database
ISI
SICI code
0019-9567(1993)61:8<3552:PEO.AA>2.0.ZU;2-P
Abstract
The antimicrobial action of .NO against Cryptococcus neoformans was in vestigated by using imidazolineoxyl N-oxide, which we recently reporte d removes 'NO via oxidation (T. Akaike, M. Yoshida, Y. Miyamoto, K. Sa to, M. Kohno, K. Sasamoto, K. Miyazaki, S. Ueda, and H. Maeda, Biochem istry 32:827-832, 1993). No appreciable fungicidal activity was observ ed in neutral 'NO solutions. Imidazolineoxyl N-oxide induced or enhanc ed fungicidal action in neutral or acidic .NO solutions, respectively. Our results provide convincing evidence that 'NO is not a microbicida l molecular species.