K. Yoshida et al., PRONOUNCED ENHANCEMENT OF .NO-DEPENDENT ANTIMICROBIAL ACTION BY AN .NO-OXIDIZING AGENT, IMIDAZOLINEOXYL N-OXIDE, Infection and immunity, 61(8), 1993, pp. 3552-3555
The antimicrobial action of .NO against Cryptococcus neoformans was in
vestigated by using imidazolineoxyl N-oxide, which we recently reporte
d removes 'NO via oxidation (T. Akaike, M. Yoshida, Y. Miyamoto, K. Sa
to, M. Kohno, K. Sasamoto, K. Miyazaki, S. Ueda, and H. Maeda, Biochem
istry 32:827-832, 1993). No appreciable fungicidal activity was observ
ed in neutral 'NO solutions. Imidazolineoxyl N-oxide induced or enhanc
ed fungicidal action in neutral or acidic .NO solutions, respectively.
Our results provide convincing evidence that 'NO is not a microbicida
l molecular species.