IMPAIRMENT OF NATURAL-KILLER-CELL ACTIVITY IN INDIAN KALA-AZAR - RESTORATION OF ACTIVITY BY INTERLEUKIN-2 BUT NOT BY ALPHA-INTERFERON OR GAMMA-INTERFERON

Authors
MANNA PP BHARADWAJ D BHATTACHARYA S CHAKRABARTI G BASU D MALLIK KK BANDYOPADHYAY S
Citation
Pp. Manna et al., IMPAIRMENT OF NATURAL-KILLER-CELL ACTIVITY IN INDIAN KALA-AZAR - RESTORATION OF ACTIVITY BY INTERLEUKIN-2 BUT NOT BY ALPHA-INTERFERON OR GAMMA-INTERFERON, Infection and immunity, 61(8), 1993, pp. 3565-3569
Citations number
18
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
61
Issue
8
Year of publication
1993
Pages
3565 - 3569
Database
ISI
SICI code
0019-9567(1993)61:8<3565:IONAII>2.0.ZU;2-6
Abstract
Indian kala-azar patients have normal numbers of peripheral blood NK c ells but impaired functional activity due to decreased binding and lys is of target cells. This impairment of NK activity could not be correc ted by exogenous recombinant human alpha or gamma interferon. However, recombinant human interleukin 2 was able to restore this activity by augmenting conjugate formation and lysis of target cells.