Mf. Feldlaufer et al., ISOLATION AND IDENTIFICATION OF LINOLEIC-ACID AS AN ANTIMICROBIAL AGENT FROM THE CHALKBROOD FUNGUS, ASCOSPHAERA-APIS, Apidologie, 24(2), 1993, pp. 89-94
Ethanol extracts of mixtures of mycelia and spores of Ascosphaera apis
, the causative agent of chalkbrood disease in honey bee, was shown to
contain an antimicrobial compound active against Bacillus larvae, the
causative agent of American foulbrood disease. Purification by high p
erformance liquid chromatography and analysis by mass spectrometry ide
ntified the active compound as 9,12-octadecadienoic acid (linoleic aci
d).