I. Marcovici et al., COLCHICINE AND POST-INFLAMMATORY ADHESIONS IN A RABBIT MODEL - A DOSE-RESPONSE STUDY, Obstetrics and gynecology, 82(2), 1993, pp. 216-218
Objective: To determine the dose-response relationship of colchicine i
n reducing inflammatory adhesive disease secondary to Neisseria gonorr
hoeae in the rabbit. Methods: Following intrauterine inoculation of a
suspension of N gonorrhoeae, the rabbits were divided into five groups
of 11 rabbits each. The control group received no medications. The re
maining four groups received 0.1, 0.5, 1, and 2 mg, respectively, of c
olchicine intramuscularly daily for 14 days. The day after the last in
jection of colchicine, the peritoneal cavity was explored and assessed
for the presence, number, and grade of adhesions. Results: With incre
asing doses of colchicine, the incidence of adhesions decreased. A lin
ear model (log [dose + 0.5]) showed, however, that as the dose of colc
hicine increased, the response tended to plateau (P < .05). Conclusion
: In this model, colchicine was effective in preventing inflammatory a
dhesions in the rabbit. Increasing doses produced a greater effect in
reducing adhesion formation. However, there was a plateau of the respo
nse at the 1-mg dose.