The purpose of this study was to elucidate the etiological pathways to
wards substance use and risky sexual behavior in female adolescent sub
stance abusers. The study had three aims: (1) to determine the relatio
ns between behavioral dysregulation, negative affectivity, and childho
od victimization with substance use and risky sexual behavior, (2) to
determine whether these relations are mediated by internalizing sympto
matology, antisocial behavior, and affiliating with an adult boyfriend
; and (3) to determine whether age of menarche moderates the relation
between the mediating variables and substance use and risky sexual beh
avior. Multiple behavioral, psychiatric interview. and self-report mea
sures were used to index behavioral dysregulation, negative affectivit
y, childhood victimization, internalizing symptomatology, antisocial b
ehavior, affiliation with adult boyfriends, substance use, and risky s
exual behavior in 125 substance abusing female adolescents and 78 cont
rols between the ages of 14-18 years. Structural equation modeling was
used to determine the etiological pathways. Results indicated that be
havioral dysregulation, negative affectivity, and childhood victimizat
ion were related to substance use and risky sexual behavior. Age of me
narche was significantly correlated with affiliation with an older boy
friend and risky sexual behavior. Antisocial behavior mediated the ass
ociations between behavioral dysregulation, negative affectivity and c
hildhood victimization with substance use and risky sexual behavior. A
ffiliation with an adult boyfriend was directly associated with substa
nce use involvement and accounted for the relationship between chronol
ogical age and risky sexual behavior. Finally, late menarche enhanced
the association between internalizing symptomatology and substance use
involvement. The results highlight the importance of behavioral dysre
gulation, negative affectivity, and childhood victimization in predict
ing substance use and risky sexual behavior, as well as the finding th
at antisocial behavior and affiliation with an adult boyfriend may be
etiologically important in predicting these outcomes. Therefore, from
a prevention and treatment standpoint, behavioral and affective dysreg
ulation, childhood victimization as well as antisocial behavior may se
rve as clinical 'gateways' for altering the developmental trajectory t
oward substance use and risky sexual behavior in high risk and substan
ce abusing youth. For example, reducing dysregulation through behavior
modification procedures that have been developed for conduct disorder
ed children would appear to be a heuristic avenue of investigation ema
nating from the results obtained in this study. (C) 1997 Elsevier Scie
nce Ireland Ltd.