PLASMA KINETICS OF MAGNESIUM AND CALCIUM STABLE-ISOTOPE TRACERS IN A HUMAN SUBJECT AFTER SIMULTANEOUS ORAL INGESTION OF MG-25 AND CA-44 DETERMINED BY THERMAL IONIZATION MASS-SPECTROMETRY
W. Stegmann et U. Karbach, PLASMA KINETICS OF MAGNESIUM AND CALCIUM STABLE-ISOTOPE TRACERS IN A HUMAN SUBJECT AFTER SIMULTANEOUS ORAL INGESTION OF MG-25 AND CA-44 DETERMINED BY THERMAL IONIZATION MASS-SPECTROMETRY, Biological mass spectrometry, 22(8), 1993, pp. 441-446
The plasma concentrations of stable isotope tracers of magnesium (Mg-2
5) and calcium (Ca-44) were determined during a 50 h period, after sim
ultaneous oral tracer ingestion in an adult man. The measurements were
performed by magnetic sector field mass spectrometry using surface io
nization ion sources. The data were used to evaluate the potential of
this method in long-term kinetic studies. It is concluded that under t
he experimental conditions specified, the isotopic tracers will be det
ectable in blood plasma with sufficient precision and accuracy for app
roximately 600 h after oral ingestion. The differences in the plasma c
oncentration curves of Mg-25 and Ca-44 were analysed by means of the c
onvolution integral method. These differences indicate inhomogeneities
in the distribution of absorption activity relative to magnesium and
calcium within the upper small intestine.