A 42-year-old Japanese woman with systemic lupus erythematosus (SLE) d
eveloped Parkinsonian-like movements. Steroid pulse therapy was most e
ffective and additional anti-Parkinsonian drugs were not required. Alt
hough psychosis, seizures and meningitis are common central nervous sy
stem (CNS) manifestations in SLE patients, Parkinsonian-like symptoms
are extremely rare. The putative genesis and treatment of CNS lupus ar
e discussed.