MEASUREMENT OF HUMAN CHORION GONADOTROPIN BY BIOLOGICAL METHODS

The clinically significant biological activities of hCG result from it s interaction with LH and TSH receptors. In vivo bioassays for measure ment of these hCG activities have many disadvantages including complex ity, expense, labor-intensity, and insensitivity. In vitro bioassays b ased on animal Leydig cell responses are widely used in research studi es, but since they are based on animal receptors, their relevance to h uman biology remains uncertain. Visible on the horizon are in vitro bi oassays constructed with human receptor genes transfected into cell sy stems by modem molecular techniques.