EFFECTS OF CHANGES IN AFTERLOAD ON REGIONAL WALL-MOTION IN ACUTE ISCHEMIC CANINE HEART

The aim of the present study was to examine effects of changes in afte rload on regional myocardial motion in acute ischemia. Ischemic and no n-ischemic segment lengths of the left ventricular free wall were meas ured by miniature ultrasonic gauges in eleven open chest dogs with the pericardium preserved. In a stable state after left anterior descendi ng coronary artery occlusion, peak left ventricular pressure was varie d by the infusion of angiotensin II (n = 8) and sodium nitroprusside ( n = 8). To exclude effects of preload on the responses, end-diastolic lengths of the non-ischemic region before and during infusion of each drug were matched with vena caval occlusion. When peak left ventricula r pressure elevated from 113 +/- 2 (mean +/- S.E.)mmHg to 145 +/- 6, i n isovolumetric contraction phase, degree of active shortening in the non-ischemic region and that of paradoxical expansion of the ischemic region did not change. In ejection phase, active shortening of the non -ischemic region decreased from 1.38 +/- 0.11 mm to 1.06 +/- 0.10 but that of the ischemic region remained unchanged. Stroke volume decrease d from 14.5 +/- 1.3 ml to 10.8 +/- 1.0. When peak left ventricular pre ssure decreased from 111 +/- 4 mmHg to 101 +/- 6, in isovolumetric con traction phase, active shortening of the non-ischemic region decreased from 0.90 +/- 0.13 mm to 0.76 +/- 0.15 and paradoxical expansion of t he ischemic region reduced from - 0.95 +/- 0.11 mm to - 0.80 +/- 0.11. In ejection phase, shortening of the non-ischemic region increased fr om 1.05 +/- 0.13 mm to 1.31 +/- 0.15 but that of the ischemic region d id not change. Stroke volume increased from 11.5 +/- 1.3 ml to 14.0 +/ - 1.4. These results indicate that in acute isehemia, changes in isovo lumetric shortening of the non-ischemic region and paradoxical expansi on of ischemic region are related with each other in isovolumetric con traction phase when afterload is altered and suggest that stroke volum e is affected by the shortening of ejection phase in the non-ischemic region.