SURGICAL-TREATMENT OF MULTIPLE BRAIN METASTASES

The authors conducted a retrospective review of the charts of 56 patie nts who underwent resection for multiple brain metastases. Of these, 3 0 had one or more lesions left unresected (Group A) and 26 underwent r esection of all lesions (Group B). Twenty-six other patients with a si ngle metastasis who underwent resection (Group C) were selected to mat ch Group B by type of primary tumor, time from first diagnosis of canc er to diagnosis of brain metastases, and presence or absence of system ic cancer at the time of surgery. Statistical analysis indicated that Groups A and B were also homogeneous for these prognostic indicators. Median survival duration was 6 months for Group A, 14 months for Group B, and 14 months for Group C. There was a statistically significant d ifference in survival time between Groups A and B (p = 0.003) and Grou ps A and C (p = 0.012) but not between Groups B and C (p > 0.5). Brain metastasis recurred in 31 % of patients in Group B and in 35% of thos e in Group C: this difference was not significant (p > 0.5). Symptoms improved after surgery in 65% of patients in Group A. 83% in Group B, and 84% in Group C. Symptoms worsened in 13% of patients in Group A. 6 % in Group B, and 0% in Group C. Groups A, B, and C had complication r ates per craniotomy of 8%, 9%, and 8%, and 30-day mortality rates of 3 %, 4%, and 0%, respectively. Guidelines for management of patients wit h multiple brain metastases are discussed. The authors conclude that s urgical removal of all lesions in selected patients with multiple brai n metastases results in significantly increased survival time and give s a prognosis similar to that of patients undergoing surgery for a sin gle metastasis.