NONENDEMIC BURKITTS-LYMPHOMA IN A PATIENT WITH BLOOMS SYNDROME

Bloom's syndrome is an autosomal recessive disorder characterized by i ntrauterine growth retardation, typical physical signs, immunodeficien cy and an increased risk of developing neoplasms at a young age, compa red to the general population. Factors possibly involved in the pathog enesis of non-endemic Burkitt's lymphoma in a five year old girl with Bloom's syndrome are discussed. These include immunodeficiency, upregu lated c-myc expression and an Epstein-Barr viral infection.