REMISSION OF PHILADELPHIA-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA ASSOCIATED WITH T(3 21) AFTER BONE-MARROW TRANSPLANTATION

We here report a male patient with an additional t(3;21)(q26;q22) in P hiladelphia positive chronic myelogenous leukemia (Ph + CML). In spite of the presence of this progression of disease marker and probably re lated to alpha-interferon therapy, this case entered into remission as a second chronic phase. At that time, he underwent allogeneic bone ma rrow transplantation. One year after BMT he showed a disappearance of leukemic clones at the cytogenetic and molecular levels. At present th e patient has 21 months of clinical and hematologic remission. It is o f interest to note that the association of alpha-interferon-hydroxyure a and bone mor-row transplantation might produce a negative selection pressure against the leukemic clone in this patient.