HIGH-VISCOSITY HPMC AS A FILM-COATING AGENT

Authors
MAFFIONE G IAMARTINO P GUGLIELMINI G GAZZANIGA A
Citation
G. Maffione et al., HIGH-VISCOSITY HPMC AS A FILM-COATING AGENT, Drug development and industrial pharmacy, 19(16), 1993, pp. 2043-2053
Citations number
2
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
19
Issue
16
Year of publication
1993
Pages
2043 - 2053
Database
ISI
SICI code
0363-9045(1993)19:16<2043:HHAAFA>2.0.ZU;2-3
Abstract
The possibility of using high viscosity grades of hydroxypropylmethylc ellulose (HPMC) as a film forming agent in a conventional coating proc ess has been investigated. Ethanol/water mixtures having different wei ght ratios (5 to 18) and containing up to 5% of HPMC revealed to be su itable. The influence of some formulation additives (talc, PVP and pla sticizers) on both the overall coating process and the in-vitro releas e profiles of ketoprofen containing coated tablets was also investigat ed and discussed.