DISPOSITION OF ENANTIOMERS OF SULPIRIDE IN HUMANS AND RATS

Authors
KAMIZONO A INOTSUME N FUKUSHIMA S NAKANO M OKAMOTO Y
Citation
A. Kamizono et al., DISPOSITION OF ENANTIOMERS OF SULPIRIDE IN HUMANS AND RATS, Biopharmaceutics & drug disposition, 14(6), 1993, pp. 475-481
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biopharmaceutics & drug disposition → ACNP
ISSN journal
01422782
Volume
14
Issue
6
Year of publication
1993
Pages
475 - 481
Database
ISI
SICI code
0142-2782(1993)14:6<475:DOEOSI>2.0.ZU;2-4
Abstract
Pharmacokinetics of sulpiride enantiomers after intravenous administra tion of (+/-)-, (+)-, and (-)-sulpiride was examined in humans and rat s. Pharmacokinetic profiles were similar in (+)- and (-)-enantiomers a fter intravenous administration of (+/-)-sulpiride. Metabolic inversio n at a chiral centre was not observed after intravenous administration of each enantiomer in rats.