RECENT ADVANCES IN MOLECULAR AND GENETIC-ANALYSIS OF RH BLOOD-GROUP STRUCTURES

Authors
COLIN Y CHERIFZAHAR B LEVANKIM C MOURO I CARTRON JP
Citation
Y. Colin et al., RECENT ADVANCES IN MOLECULAR AND GENETIC-ANALYSIS OF RH BLOOD-GROUP STRUCTURES, Journal of medical primatology, 22(1), 1993, pp. 36-43
Citations number
53
Categorie Soggetti
Zoology,"Veterinary Sciences
Journal title
Journal of medical primatology → ACNP
ISSN journal
00472565
Volume
22
Issue
1
Year of publication
1993
Pages
36 - 43
Database
ISI
SICI code
0047-2565(1993)22:1<36:RAIMAG>2.0.ZU;2-Z
Abstract
The Rh antigens are carried by 30-32 kDa integral proteins of the red cell membrane. The Rh locus is composed of two genes: RhD, which encod es the major D antigen and is present only in Rh-positive genomes, and RhCcEe, which encodes both the Cc and Ee polypeptides, most likely by alternative splicing events. The D and non-D Rh mRNAs have been clone d. Their sequence homology suggest that the two Rh genes have evolved by duplication of a common ancestor.