PROTEIN-C AND PROTEIN-S DEFICIENCY CAUSING CHILDHOOD STROKE

The annual incidence of cerebrovascular disease in children is 2.5/100 ,000 and cerebral infarction is being increasingly recognised in neona tes.1 Deficiency of proteins C and S and their roles in thrombosis hav e only recently been recognised.2 Immunologic and functional assays of these proteins now make it possible to determine whether deficiency o f them is associated in any particular case of childhood cerebrovascul ar accident (CVA).3 We describe two patients, both presenting with str oke in childhood, who were found to be deficient, one in protein C and one in protein S.