DEVELOPMENT OF ATYPICAL AMIODARONE KERATOPATHY IN A CORNEAL GRAFT

The presence of fine epithelial deposits in a whorled pattern (cornea verticillata) as a consequence of treatment with amiodarone is well do cumented. We present a case of amiodarone keratopathy in a grafted cor nea which is atypical in that the orientation of the pattern is rotate d through nearly 90-degrees to that normally observed. This observatio n runs counter to the hypothesis that cornea verticillata is a manifes tation of the line of lid closure. We speculate on the mechanism direc ting the migrational pathways of epithelial cells.