CAFFEIC ACID PHENETHYL ESTER AS A LIPOXYGENASE INHIBITOR WITH ANTIOXIDANT PROPERTIES

Authors
SUDINA GF MIRZOEVA OK PUSHKAREVA MA KORSHUNOVA GA SUMBATYAN NV VARFOLOMEEV SD
Citation
Gf. Sudina et al., CAFFEIC ACID PHENETHYL ESTER AS A LIPOXYGENASE INHIBITOR WITH ANTIOXIDANT PROPERTIES, FEBS letters, 329(1-2), 1993, pp. 21-24
Citations number
18
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
329
Issue
1-2
Year of publication
1993
Pages
21 - 24
Database
ISI
SICI code
0014-5793(1993)329:1-2<21:CAPEAA>2.0.ZU;2-7
Abstract
Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5-lipoxygenase in the micromolar concentration range. The in hibition is of an uncompetitive type, i.e. the inhibitor binds to the enzyme-substrate complex but not to the free enzyme. Caffeic acid phen ethyl ester also exhibits antioxidant properties. At a concentration o f 10 muM, it completely blocks production of reactive oxygen species i n human neutrophils and the xanthine/xanthine oxidase system.