MOLECULAR MECHANISM OF INHIBITION OF MAMMALIAN PROTEIN-SYNTHESIS BY SOME 4-CHAIN AGGLUTININS - PROPOSAL OF AN EXTENDED CLASSIFICATION OF PLANT RIBOSOME-INACTIVATING PROTEINS (RIBOSOMAL-RNA N-GLYCOSIDASES)

Authors
CITORES L FERRERAS JM IGLESIAS R CARBAJALES ML ARIAS FJ JIMENEZ P ROJO MA GIRBES T
Citation
L. Citores et al., MOLECULAR MECHANISM OF INHIBITION OF MAMMALIAN PROTEIN-SYNTHESIS BY SOME 4-CHAIN AGGLUTININS - PROPOSAL OF AN EXTENDED CLASSIFICATION OF PLANT RIBOSOME-INACTIVATING PROTEINS (RIBOSOMAL-RNA N-GLYCOSIDASES), FEBS letters, 329(1-2), 1993, pp. 59-62
Citations number
21
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
329
Issue
1-2
Year of publication
1993
Pages
59 - 62
Database
ISI
SICI code
0014-5793(1993)329:1-2<59:MMOIOM>2.0.ZU;2-V
Abstract
The four chain agglutinins from Abrus precatorius, Viscum album and Ri cinus communis promote depurination of the 28 S rRNA from rabbit retic ulocyte ribosomes characteristic of the common ribosome-inactivating p roteins (RIPs). These agglutinins inhibited mammalian protein synthesi s at nanomolar concentrations but they do not affect plant protein syn thesis under the same conditions. Therefore, they should also be consi dered as true RIPs but of a new class, the four-chain RIPs. An extende d classification of RIPs is presented based on the former one from Sti rpe et al. [Bio/technology 10 (1992) 405-412].