DEFECTIVE ASSOCIATION OF DYSTROPHIN WITH SARCOLEMMAL GLYCOPROTEINS INTHE CARDIOMYOPATHIC HAMSTER HEART

Authors
IWATA Y NAKAMURA H MIZUNO Y YOSHIDA M OZAWA E SHIGEKAWA M
Citation
Y. Iwata et al., DEFECTIVE ASSOCIATION OF DYSTROPHIN WITH SARCOLEMMAL GLYCOPROTEINS INTHE CARDIOMYOPATHIC HAMSTER HEART, FEBS letters, 329(1-2), 1993, pp. 227-231
Citations number
20
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
329
Issue
1-2
Year of publication
1993
Pages
227 - 231
Database
ISI
SICI code
0014-5793(1993)329:1-2<227:DAODWS>2.0.ZU;2-F
Abstract
In ventricular muscle from 30- to 60-day-old Bio 14.6 cardiomyopathic hamsters, dystrophin-associated glycoproteins of 43, 50 and 150 kDa ar e markedly reduced in abundance. In particular, the 50-kDa glycoprotei n is totally deficient in the sarcolemma of myopathic ventricular myoc ytes as revealed by immunofluorescence microscopy. The dystrophin-glyc oprotein complex formation is defective in the cardiomyopathic hamster heart. because dystrophin and the glycoproteins behave independently when digitonin-solubilized ventricular homogenates are fractionated on wheat germ agglutinin beads or anti-dystrophin immunoaffinity beads.