CUTANEOUS AND OCULAR CHANGES ASSOCIATED WITH THE USE OF CHLORPROMAZINE

A 57-year-old schizoaffective disorder patient was placed on chlorprom azine because of its sedative properties and low profile for extrapyra midal side effects. After two years of treatment, the patient develope d photosensitivity and blue-gray pigmentation of the skin of the face, neck and dorsum of hands. Significant pigment deposits were also obse rved in eye lens and cornea. An oval translucent lesion lateral to the left angle of the mouth was removed and the biopsy showed a basal cel l carcinoma. The cutaneous and eye pigmentation were only partially re versible after the discontinuation of chlorpromazine. There has been n o recurrence of basal cell carcinoma.