M. Hartmann et al., EFFECTS OF DEXTRAN AND CRYSTALLOIDS ON SUBCUTANEOUS OXYGEN-TENSION AND COLLAGEN ACCUMULATION - A RANDOMIZED STUDY IN SURGICAL PATIENTS, European surgical research, 25(5), 1993, pp. 270-277
Twenty-nine patients, subjected to major abdominal surgery, were rando
mized to different types of postoperative fluid replacement, given on
the basis of subcutaneous oxygen tension measurements (PScO2). One reg
imen consisted of crystalloids, the other of a combination of crystall
oids and colloids (dextran 70). Perioperative fluid replacement was gi
ven according to clinical criteria and postoperatively according to po
larographic PSCO2 measurements. PSCO2 Was measured by a silicone cathe
ter implanted in the upper arm. Two tubes of expanded polytetrafluoroe
thylene (ePTFE) were implanted next to the silicon catheter. They were
removed on day 5 and 7, and analysed for hydroxyproline content. Tota
l postoperative fluid support was equal in the two groups, and so was
the hydroxyproline content on day 7. In conclusion, postoperative flui
d substitution with dextran has no advantages over crystalloids only,
with regard to granulation tissue formation if postoperative fluid sup
port is optimum, according to PSCO2 measurements.