HISTOMORPHOLOGICAL EVALUATION OF WOUND-HEALING OF RABBIT OVIDUCT AFTER MICROSURGICAL REANASTOMOSIS WITH THE USE OF AUTOLOGOUS FIBRIN ADHESIVE, HUMAN FIBRIN ADHESIVE OR POLY-GLYCOLIC ACID SUTURE

The morphology of the healing process of microsurgical reanastomosis o f the rabbit oviduct with the use of fibrin adhesive, autologous and h eterologous, and conventional sutures is described. Both oviducts in 4 8 rabbits were cut and reanastomoses were performed. The rabbits were killed at different intervals after the operations, ranging from 2 h t o 28 days, and the anastomoses were evaluated by histomorphological ex amination. The autologous fibrin adhesive was absorbed after a week an d an uncomplicated healing was observed. Heterologous fibrin adhesive caused a granulomatous inflammation interpreted as an immune reaction of the host to the foreign protein, and conventional suturing resulted in severe tissue damage with an intensive inflammatory reaction.