THE APPEARANCE OF KAPOSI-SARCOMA DURING CORTICOSTEROID-THERAPY

Background. Four epidemiologic types of Kaposi sarcoma (KS) are known: classic KS, endemic African KS, epidemic or acquired immunodeficiency syndrome-related KS, and KS associated with immunosuppressive therapy . In most of the latter patients, KS was reported to have developed af ter organ transplantation, particularly renal transplantation. Thirty- nine patients who have not had a transplant have been reported to have KS associated with corticosteroid therapy. Methods. The authors studi ed 10 patients with the appearance of KS during corticosteroid therapy (6 men, 4 women; age range, 42-79 years) who were treated with cortic osteroids for autoimmune disorders (5 patients), lymphoproliferative d isorders (2 patients), and diseases unrelated to the immune system (3 patients). Results. Genetically programmed susceptibility to corticost eroid-related KS was suggested by the descent of the study patients as well as most of those reported previously. The prognosis was guarded in all the study patients. Conclusions. Corticosteroids should be with drawn to achieve clinical remission.