ULTRASONIC NEBULIZATION OF PENTAMIDINE ISETHIONATE

Authors
TAYLOR KMG HOARE C
Citation
Kmg. Taylor et C. Hoare, ULTRASONIC NEBULIZATION OF PENTAMIDINE ISETHIONATE, International journal of pharmaceutics, 98(1-3), 1993, pp. 45-49
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
98
Issue
1-3
Year of publication
1993
Pages
45 - 49
Database
ISI
SICI code
0378-5173(1993)98:1-3<45:UNOPI>2.0.ZU;2-P
Abstract
The properties of pentamidine isethionate aerosols produced by an ultr asonic nebuliser frequently used in clinical practice have been invest igated. The mass median diameter of the aerosols was initially 5.1-5.6 mum, depending on the volume of solution atomized and the output sett ing of the nebuliser. The aerosol size tended to decrease, and the sol ution temperature increase with time. Between 57 and 74% of drug place d in the nebuliser was delivered during use, the remainder being assoc iated with the device.