Ja. Leary et al., INVESTIGATION OF LOSS OF HETEROZYGOSITY AT SPECIFIC LOCI ON CHROMOSOMES 3P, 6Q, 11P, 17P AND 17Q IN OVARIAN-CANCER, International journal of gynecological cancer, 3(5), 1993, pp. 293-298
In an attempt to further define the genetic events in the pathogenesis
and progression of human ovarian cancer, an analysis of constitutiona
l and ovarian carcinoma DNA samples revealed loss of heterozygosity (L
OH) at specific loci on chromosomes 3p (38 %), 6q (23 %), 11p (33 %),
17p (82 %) and 17q (62%). In contrast, LOH was not observed in benign
or borderline tumors. No significant association could be demonstrated
between LOH at the loci studied and tumor stage, histologic subtype,
grade or patient outcome. Further analyses of large tumor panels are n
ow required to determine the relationship between LOH at these loci an
d the clinicopathological behavior of ovarian tumors.