Rmr. Nogueira et al., DENGUE EPIDEMIC IN THE STATE OF RIO-DE-JANEIRO, BRAZIL, 1990-1 - CO-CIRCULATION OF DENGUE-1 AND DENGUE-2 SEROTYPES, Epidemiology and infection, 111(1), 1993, pp. 163-170
During 1990 and 1991, dengue fever was detected in the State of Rio de
Janeiro, Brazil. It occurred in two epidemic waves; one, from January
to August 1990, caused predominantly by dengue virus type 1 (DEN-1) t
he other from October 1990 to May 1991 caused by type 2 virus (DEN-2).
Dengue was confirmed by virus isolation and/or IgM capture enzyme-lin
ked immunosorbent assay (MAC-ELISA) in 2109/5964 (35-4 %) of the cases
. DEN-2 virus was isolated from 180 patients. HAI tests indicated that
of these previous infection with DEN-1 had occurred in 130 (72 %). Th
e epidemic was classified as dengue fever, but severe and even fatal c
ases occurred in association with secondary infection.