Md. Habgood et al., THE NATURE OF THE DECREASE IN BLOOD CEREBROSPINAL-FLUID BARRIER EXCHANGE DURING POSTNATAL BRAIN-DEVELOPMENT IN THE RAT, Journal of physiology, 468, 1993, pp. 73-83
1. The blood-cerebrospinal fluid (CSF) exchange of a wide range of pas
sively transported lipid insoluble compounds (0.43-5.4 nm molecular ra
dius) has been investigated in rats at different stages of postnatal d
evelopment (2 days old to adult). A novel 'litter-based' model for inv
estigating blood-CSF barrier exchange in immature animals is described
. 2. At each age investigated there was a clear inverse correlation be
tween molecular radius and blood-CSF barrier exchange, in addition to
an overall decrease in blood-CSF barrier exchange with increasing age.
3. The decrease in blood-CSF barrier exchange with age was not consis
tent with a reduction in pore diameters, nor does it appear to be due
to an increase in the CSF sink effect with age. It seems likely to be
due to a relative decrease in the number of a population of large diam
eter pores.