MULTIORGAN FAILURE AFTER ADMINISTRATION O F PPSB IN A PATIENT WITH ISOLATED FACTOR-VII DEFICIENCY - CASE-REPORT

A 56-year-old man was scheduled for an orthopaedic operation on the sh oulder to repair a rupture of the rotator cuff. Prior to surgery, he w as diagnosed as having hypoproconvertinaemia associated with a factor concentration of 10 %. Following the preoperative administration of 50 IU/kg of KG PPSB, severe disseminated intravascular coagulation (DIC) developed, with subsequent multiorgan failure. For further operative procedures that later became necessary to treat the sequelae of the DI C, KG PPSB was withheld, replacement with fresh frozen plasma being ap plied. A major reconstructive operation was carried out with a lower d ose of 15 IU/kg KG PPSB in the form of another preparation with a high er content of proconvertin being administered. Both the intraoperative and postoperative phases were free of complications, and no further d isseminated intravascular coagulation was observed The possible reason s for the dramatic situation in this patient are discussed.