In an effort to evaluate conformity with published guidelines for diag
nostic allergy skin testing in their locality, a committee of members
of the Orange County (California) Society of Allergy and Clinical Immu
nology surveyed their membership for the number, identity, and rates o
f sensitization of aeroallergens in a selected patient population. Tes
t data were analyzed on patients who were judged appropriate to underg
o immunotherapy. Complete test results of 271 patients were obtained f
rom one third of local allergy specialists. A total of 115 different a
eroallergen extracts were identified. By category, tree pollen allerge
ns (32) were followed in declining order by weed pollens (28), molds (
22), environmentals (18), and grass pollen extracts (15), for the tota
l of 115. The average number of aeroallergens used by a practice in a
comprehensive evaluation was 77 (range, 47-114). When only unequivocal
ly positive reactions were considered (3+ equivalent or greater), Berm
uda grass pollen extracts elicited the highest rate, 85%, and the envi
ronmental, rat dander, was the lowest at 1.8%. At least 20% of the pat
ients reacted strongly on skin tests to 97% of the extracts. The dispa
rity between the recommendations of a maximum of 30 aeroallergens for
a comprehensive evaluation and actual practice procedures merits effor
ts at resolution.