DETECTION OF PLATELET-ACTIVATING-FACTOR IN PLASMA OF PATIENTS WITH STREPTOCOCCAL NEPHRITIS

Citation
S. Mezzano et al., DETECTION OF PLATELET-ACTIVATING-FACTOR IN PLASMA OF PATIENTS WITH STREPTOCOCCAL NEPHRITIS, Journal of the American Society of Nephrology, 4(2), 1993, pp. 235-242
Citations number
33
Categorie Soggetti
Urology & Nephrology
ISSN journal
10466673
Volume
4
Issue
2
Year of publication
1993
Pages
235 - 242
Database
ISI
SICI code
1046-6673(1993)4:2<235:DOPIPO>2.0.ZU;2-E
Abstract
The purpose of this study was to evaluate whether platelet-activating factor (PAF) is released in the plasma of patients with acute poststre ptococcal glomerulonephritis, because previous studies have shown an i nvolvement of platelets in the active phase of this disease. The resul ts of this study indicate that PAF bioactive material is released in s ignificant amounts in the plasma of 49 out of 50 patients with acute p oststreptococcal glomerulonephritis. The observed release of PAF was n ot a direct consequence of the bacterial infection, because it was min imal or absent in patients with streptococcal infection without glomer ular involvement. PAF bioactive material extracted and purified from t he plasma of patients was shown to be chemically and biologically iden tical to the synthetic C-16 PAF (1-O-hexadecyl-2-acetyl-sn-glyceryl 3- phosphorylcholine).