Bp. Currie et al., FALSE-NEGATIVE CEREBROSPINAL-FLUID CRYPTOCOCCAL LATEX AGGLUTINATION TESTS FOR PATIENTS WITH CULTURE-POSITIVE CRYPTOCOCCAL MENINGITIS, Journal of clinical microbiology, 31(9), 1993, pp. 2519-2522
Three cases of false-negative cerebrospinal fluid latex agglutination
test results for patients with culture-positive cryptococcal meningiti
s are reported. False-negative results occurred in settings of low cry
ptococcal antigen concentrations in cerebrospinal fluid and were depen
dent on the latex agglutination test kit used. Investigation of each c
ase revealed that prozone phenomena or interference from bound antibod
y or protein could not account for the false-negative results.