Gd. Stoner et al., LUNG-TUMORS IN STRAIN A MICE - APPLICATION FOR STUDIES IN CANCER CHEMOPREVENTION, Journal of cellular biochemistry, 1993, pp. 95-103
Strain A mice develop a high incidence of spontaneous lung tumors duri
ng their lifetime. These tumors may be found in some animals as early
as 3 to 4 weeks of age, increasing to nearly 100% by 24 months of age.
The strain A mouse is also highly susceptible to the induction of lun
g tumors by several classes of chemical carcinogens and has been used
extensively as a mouse lung tumor bioassay for assessing the carcinoge
nic activity of a variety of chemicals. In addition to its use in carc
inogen detection, the strain A mouse lung tumor model has been employe
d extensively for the identification of inhibitors of chemical carcino
genesis. A number of chemopreventive agents including beta-naphthoflav
one, butylated hydroxyanisole, ellagic acid, phenethyl isothiocyanate,
phenylpropyl isothiocyanate, phenylbutyl isothiocyanate, phenylhexyl
isothiocyanate, indole-3-carbinol, etc., have been shown to inhibit ch
emically induced lung tumors in strain A mice. In most instances, inhi
bition of lung tumorigenesis has been correlated with effects of the c
hemopreventive agent on the metabolic activation and/or detoxification
of carcinogens. To date, no chemopreventive agent has been shown to i
nhibit lung tumorigenesis in strain A mice when administered after the
carcinogen, i.e., during the promotion/progression stages of tumor de
velopment. Efforts should be made to develop a standardized protocol i
n strain A mice for evaluating chemopreventive agents as inhibitors of
both the initiation and progression stages of lung tumor development.
(C) 1993 Wiley-Liss, Inc.