EFFECTS OF H-2 BLOCKERS AND OMEPRAZOLE ON PEPTIC SECRETION - A PROSPECTIVE, RANDOMIZED STUDY IN DUODENAL-ULCER SUBJECTS

Aim of the present study has been to investigate the possible modifica tions of peptic secretion after a period with H-2 blockers and omepraz ole, evaluating in the same patient pepsinogen group A levels in gastr ic mucosa and pepsin in gastric juice. 54 active duodenal ulcer were s tudied : during an upper gastrointestinal endoscopy a sample of gastri c juice and one fundus biopsy were taken before and after four weeks 3 00 mg/daily ranitidine (23 patients), 40 mg/daily famotidine (7 patien ts), 300 mg/daily nizatidine (12 patients) therapy and 40 mg/daily ome prazole (12 patients) therapy. Results : H-2-blockers and omeprazole t reatment determines a non statistically significant decrease of pepsin in gastric juice and in pepsinogen group A in gastric mucosa.