A MODEL FOR THROMBOEMBOLIZATION ON BIOMATERIALS

A model was developed to describe the kinetics of protein and platelet deposition and embolization on biomaterials. The model assumes that p roteins can be adequately represented by fibrinogen, albumin, and Fact or XII, that protein adsorption is Langmuir-type, that surfaces are ho mogeneous, and that all adsorption and deposition steps are first orde r. Eleven model parameters were determined from literature experimenta l data from ex vivo experiments utilizing canine and baboon blood on S ilastic, one parameter came from adsorption of Factor XII on glass, an d three parameters were obtained by minimizing differences between exp erimental and predicted fibrinogen adsorption, and platelet deposition and embolization behavior. The model well predicted observed behavior for fibrinogen adsorption, platelet deposition, and platelet emboliza tion on Silastic, and platelet embolization from both polyacrylamide a nd HEMA-MAAC.