HIGH-DOSE NUTRIZYM-22 IN CYSTIC-FIBROSIS

New high dose pancreatic enzyme preparations could be potentially help ful to cystic fibrosis (CF) patients. The purpose of this study was to compare the efficacy of the new high dose pancreatic enzyme preparati on, Nutrizym 22 with the standard preparation Nutrizym GR. Twenty-five CF children (aged 7-16 years) entered the study and 22 completed it; 3 did not, due to non-compliance. All were taking Nutrizym GR for at l east 2 weeks before entering the study. A randomised double blind, cro ssover method using standard Nutrizym GR or double strength Nutrizym 2 2 capsules was carried out over two consecutive 14-day periods. Crosso ver analyses of variance showed no statistically significant differenc es in actual weight gain, appetite, abdominal pain, stool consistency or faecal fat during the prestudy and study periods. It is concluded t hat half the capsule numbers of the high strength preparation are just as effective as the standard capsule dosage.