PATTERNS OF OCCURRENCE OF 2ND PRIMARY NONMAMMARY MALIGNANCIES IN BREAST-CANCER PATIENTS - RESULTS FROM 1382 CONSECUTIVE AUTOPSIES

An autopsy series on the patterns of occurrence of second primary non- mammary malignancies (SPNM) in breast cancer patients is presented. SP NM occurred in 11.4% of breast cancer patients at a mean interval of 8 3.9 months. Seventy-five per cent of them occurred by the first decade following breast cancer. The most common system of SPNM occurrence wa s the female genital system, followed by the gastrointestinal system. The single organs most commonly involved were the colon and rectum, ov ary and uterine cervix. There was no evident association between admin istration of radio-therapy or chemotherapy for the breast cancer and t he risk for SPNM development except in the case of post-radiation sarc omas at or near the site of post-mastectomy radiotherapy. Death was ca used by the breast cancer in 28.7% of patients and by the SPNM in 53.5 %. In 10.6% of the cases the SPNM was clinically interpreted as metast atic breast cancer until autopsy.