The author performed a randomized prospective study of the effects of
needle size and of age, sex, myelogram type and operators on the incid
ence of headache following myelography. In 113 patients randomized to
22 G and 25 G needle groups, data were obtained by questionnaire on th
e frequency of headache up to five days following the procedure. The i
nfluence of needle size was statistically insignificant (63 %, 48 %, p
> 0.05). Age (p = 0.0002), sex (p = 0.01), myelogram type (p = 0.002)
and myelographer (p = 0.03) significantly affected the frequency of h
eadache. The size of the dural perforation appears to be less importan
t than factors relating to age, sex, myelogram type and individual mye
lographers in the development of headache after myelography.