INTRACRANIAL CALCIFICATION IN SIBLINGS WITH NEPHROGENIC DIABETES-INSIPIDUS - CT AND MRI

Computed tomography and magnetic resonance imaging (MRI) were used to examine three male siblings with nephrogenic diabetes insipidus (NDI). The two elder brothers had verying degrees of unusual intracranial ca lcification; the eldest also showed involvement of the cerebral white matter on MRI. The severity of intracranial calcification was related to the time before initiation of treatment and inversely to mental abi lity. Brain damage and mental retardation in NDI may be caused by a de lay in initiating treatment; early detection and treatment are importa nt to prevent brain damage.