THE IMPACT OF CIGARETTE-SMOKING ON THE PLASMA-CONCENTRATIONS OF GONADOTROPINS, OVARIAN-STEROIDS AND ANDROGENS AND UPON THE METABOLISM OF ESTROGENS IN THE HUMAN FEMALE

Citation
Ej. Thomas et al., THE IMPACT OF CIGARETTE-SMOKING ON THE PLASMA-CONCENTRATIONS OF GONADOTROPINS, OVARIAN-STEROIDS AND ANDROGENS AND UPON THE METABOLISM OF ESTROGENS IN THE HUMAN FEMALE, Human reproduction, 8(8), 1993, pp. 1187-1193
Citations number
25
Categorie Soggetti
Reproductive Biology
Journal title
ISSN journal
02681161
Volume
8
Issue
8
Year of publication
1993
Pages
1187 - 1193
Database
ISI
SICI code
0268-1161(1993)8:8<1187:TIOCOT>2.0.ZU;2-Q
Abstract
This study compares the plasma gonadotrophin, oestradiol, and androgen and salivary progesterone concentrations in a single menstrual cycle between 25 normal pre-menopausal women who smoke cigarettes and 21 who are non-smokers. The effect of smoking on luteinizing hormone (LH) pu lsatility and the urinary excretion of oestrogens is also described. C igarette smoking did not consistently suppress LH pulsatility. There w as no significant difference in the length of either the follicular or luteal phases. There were no significant differences in the mean plas ma oestradiol concentrations in the follicular phase in smokers compar ed to non-smokers. There were no significant differences in the mean s alivary progesterone concentration in the luteal phase in smokers comp ared to non-smokers. There was no significant differences in plasma co ncentrations of testosterone, androstenedione and dehydroepiandrostero ne sulphate. There was also no significant difference between the urin ary concentrations of oestradiol, oestrone or oestriol. We have been u nable to demonstrate a detrimental effect of cigarette smoking on any of the important endocrine characteristics of the menstrual cycle, and we conclude that these data suggest that the anti-oestrogenic effect of smoking does not work through alterations in pituitary or follicula r endocrine function or in alterations in the metabolism of oestrogens .