T. Niwa et al., SUPPRESSIVE EFFECT OF AN ORAL SORBENT ON THE ACCUMULATION OF P-CRESOLIN THE SERUM OF EXPERIMENTAL UREMIC RATS, Nephron, 65(1), 1993, pp. 82-87
Serum p-cresol and phenol are markedly accumulated in uremic patients.
To determine if an oral sorbent (AST-120) can decrease their serum co
ncentrations in the uremic state, an oral sorbent was administered to
experimental nephrectomized uremic rats. In uremic rats fed with oral
sorbent, the serum concentration and the urinary excretion of p-cresol
were markedly and significantly lower than those in control uremic ra
ts, while those of phenol tended to be low in the uremic rats with ora
l sorbent as compared with control uremic rats. The concentrations of
serum creatinine and blood urea nitrogen were significantly decreased
in the uremic rats with oral sorbent. These findings demonstrate that
oral sorbent adsorbs especially p-cresol in the intestine and prevents
the accumulation of p-cresol in the serum of uremic rats.