BIS(O,O-DIISOPROPOXY PHOSPHINOTHIOYL) DISULFIDE - A HIGHLY EFFICIENT SULFURIZING REAGENT FOR COST-EFFECTIVE SYNTHESIS OF OLIGO(NUCLEOSIDE PHOSPHOROTHIOATE)S
Wj. Stec et al., BIS(O,O-DIISOPROPOXY PHOSPHINOTHIOYL) DISULFIDE - A HIGHLY EFFICIENT SULFURIZING REAGENT FOR COST-EFFECTIVE SYNTHESIS OF OLIGO(NUCLEOSIDE PHOSPHOROTHIOATE)S, Tetrahedron letters, 34(33), 1993, pp. 5317-5320
A new sulfurizing reagent is reported for the automated synthesis of p
hosphorothioate analogues of oligonucleotides via the phosphoramidite
method. Bis(O,O-diisopropoxy phosphinothioyl) disulfide (S-Tetra, 1) i
s relatively inexpensive to prepare, easy to handle, and efficiently s
ulfurizes internucleotide phosphites , thus allowing the practical syn
thesis of oligo(nucleoside phosphorothioate)s with exceptionally high
sulfur content.