BIS(O,O-DIISOPROPOXY PHOSPHINOTHIOYL) DISULFIDE - A HIGHLY EFFICIENT SULFURIZING REAGENT FOR COST-EFFECTIVE SYNTHESIS OF OLIGO(NUCLEOSIDE PHOSPHOROTHIOATE)S

Authors
STEC WJ UZNANSKI B WILK A HIRSCHBEIN BL FEARON KL BERGOT BJ
Citation
Wj. Stec et al., BIS(O,O-DIISOPROPOXY PHOSPHINOTHIOYL) DISULFIDE - A HIGHLY EFFICIENT SULFURIZING REAGENT FOR COST-EFFECTIVE SYNTHESIS OF OLIGO(NUCLEOSIDE PHOSPHOROTHIOATE)S, Tetrahedron letters, 34(33), 1993, pp. 5317-5320
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
33
Year of publication
1993
Pages
5317 - 5320
Database
ISI
SICI code
0040-4039(1993)34:33<5317:BPD-AH>2.0.ZU;2-W
Abstract
A new sulfurizing reagent is reported for the automated synthesis of p hosphorothioate analogues of oligonucleotides via the phosphoramidite method. Bis(O,O-diisopropoxy phosphinothioyl) disulfide (S-Tetra, 1) i s relatively inexpensive to prepare, easy to handle, and efficiently s ulfurizes internucleotide phosphites , thus allowing the practical syn thesis of oligo(nucleoside phosphorothioate)s with exceptionally high sulfur content.