BRAIN ANGIOTENSIN AT-2 RECEPTOR ANTAGONISM AND WATER-INTAKE

Authors
ROWLAND NE FREGLY MJ
Citation
Ne. Rowland et Mj. Fregly, BRAIN ANGIOTENSIN AT-2 RECEPTOR ANTAGONISM AND WATER-INTAKE, Brain research bulletin, 32(4), 1993, pp. 391-394
Citations number
12
Categorie Soggetti
Neurosciences
Journal title
Brain research bulletin → ACNP
ISSN journal
03619230
Volume
32
Issue
4
Year of publication
1993
Pages
391 - 394
Database
ISI
SICI code
0361-9230(1993)32:4<391:BAARAA>2.0.ZU;2-4
Abstract
Intracerebroventricular administration of the angiotensin AT-2 recepto r antagonist, PD 123319, inhibited drinking induced in rats by hyperto nic NaCl, carbachol, isoproterenol, hypovolemia, and water deprivation , but had no effect on food intake. In contrast. the AT-1 antagonist, losartan potassium. had no effect on these intakes. A model of thirst is presented that incorporates an AT-2 receptor in a final common path way for drinking.