PORTAL-VEIN INFUSION OF CANCER CHEMOTHERAPEUTIC AGENT EMULSIFIED WITHLIPIODOL IN REGENERATING LIVER AFTER PARTIAL-HEPATECTOMY IN RATS

Portal vein infusion of aclarubicin (ACR) emulsified with Lipiodol (LP ) in regenerating liver after 70% partial hepatectomy in rats was eval uated for its safety and usefulness. DNA synthesis in regenerating liv er was transiently suppressed by LP, ACR or LP + ACR, but no obvious i nhibition was seen in aminopyrine N-demethylase activity and liver wei ghts. LP significantly enhanced hepatic tissue levels of ACR and its a ctive metabolites by long-term retention in the sinusoidal space. This study demonstrates that in rats LP has a powerful effect on the long- term retention of anticancer agents in the sinusoidal space after infu sion into the portal vein, without aggravating hepatic damage by antic ancer agents.