A prospective, randomized, double-blind study was performed to compare
the analgesic efficacy and side effects of epidural fentanyl, 25 mug
vs 50 mug, when used to supplement epidural anaesthesia for elective C
aesarean section. Fifty ASA I and II patients were randomized into two
groups Group I (n = 24) received 25 mug and Group II (n = 26) receive
d 50 mug of epidural fentanyl after the epidural test dose. No differe
nces between the two groups were found on any measures of intraoperati
ve pain, nausea, drowsiness, respratory depression, hypotension, pruri
tus and neonatal outcome. The low levels of pain experienced by patien
ts indicates that doses higher than 50 mug of epidural fentanyl are us
ually unnecessary for optimal analgesia.